Actin related proteins in the mechanoelectrical transduction of the hair cells and hereditary hearing loss DFNA20/26

毛细胞机电转导中的肌动蛋白相关蛋白和遗传性听力损失 DFNA20/26

• 批准号: 19591953
• 负责人: KATORI Yukio
• 金额: $ 2.91万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2008
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19591953/
• 关键词: 神経科学; 細胞組織; 蛋白質; 細胞・組織

モルモット蝸牛試料を界面活性剤で脱膜処理後に細胞質可溶性成分を除外して電界放射型走査電子顕微鏡により観察し、従来に無い広い範囲での不動毛細胞骨格の超微細構造の観察を可能にした。音受容に関係する有毛細胞不動毛のアクチンおよび関連蛋白分子の三次元的配列を明らかにした。加えて細胞外カルシウム濃度によるそれらの構造の変化を明らかにした。

In addition to cytoplasmic soluble components after the removal of the interfacial active agent from the snail sample, it is possible to observe the ultra-fine structure of the non-moving hair cell skeleton by electron microscopy. The three-dimensional alignment of hair cells and associated protein molecules is now clear. The structure of the cell was changed.

项目成果

2008) The dimensions and structural attachments of tip links in mammalian cochlear hair cells and the effects of exposure to different levels of extracellular calcium

2008）哺乳动物耳蜗毛细胞尖端连接的尺寸和结构附件以及暴露于不同水平的细胞外钙的影响

• 发表时间: 2008
• 期刊: Neuroscience 154
• 作者: Furness DN;Katori Y;Kumar N;and Hackney CM
• 通讯作者: and Hackney CM

Effects of Exposure to Different Concentrations of Extracellular Calcium on Tip-Link Dimensions

暴露于不同浓度的细胞外钙对尖端连接尺寸的影响

• 发表时间: 2008
• 作者: David Furness;Nirmal Kumar;Yukio Katori;Carole Hackney
• 通讯作者: Carole Hackney

The dimensions and structural attachments of tip links in mammalian cochlear hair cells and the effects of exposure to different levels of extracellular calcium

• DOI: 10.1016/j.neuroscience.2008.02.010
• 发表时间: 2008-06-12
• 期刊: NEUROSCIENCE
• 影响因子: 3.3
• 作者: Furness, D. N.;Katori, Y.;Hackney, C. M.
• 通讯作者: Hackney, C. M.