Molecular genetic analysis of recurrence of endogenous uveitis

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Disease susceptibility genes and prognostic factors of endogenous uveitis were examined in this project. First, descriptive questionnaires were collected from 25 eye centers in 14 countries. Behcet disease is still a common cause of blindness in Asia. It was less common in children than in adults in East/South Asian countries. Second, DNA samples were collected to analyze molecular genetic factors associated with clinical characteristics and prognostic factors of uveitic diseases. Some gene polymorphisms were associated with the diseases : Behcet disease, sarcoidosis, Vogt-Koyanagi-Harada disease, and vitiligo vulgaris. Polymorphisms expected to the recurrence of uveitis was analyzed in Behcet disease compared with Vogt-Koyanagi-Harada disease.