Reduction of radiation damages on salivary glands by the aminothiols.

口干症是头颈癌放射治疗中和治疗后最常见的并发症之一，因为唾液腺是包括在放射治疗范围内的，会造成不可修复的损害。为了防止辐射损伤，美国临床上使用了抗辐射药物氨磷汀，我们从辐射前小鼠唾液腺腺泡细胞的分泌能力出发，研究了氨磷汀对辐射后小鼠唾液腺细胞分泌能力的影响。我们证实，与非氨磷汀治疗相比，阿米福汀在辐射过程中对小鼠唾液腺的腺泡细胞的损伤有抑制作用。

Xerostomia is one of the most common complications during and after radiation therapy for head and neck cancer, because irreparable damage is caused to the salivary glands, which are included in the radiation fields. In order to prevent of the damage, the radioprotect drug, amifostine, is clinically used in USA..we have examined the effect of amifostine from the secretory ability of mice salivary gland acinar cells before radiation. We confirmed that the damage of the acinar cells of mice salivary glands were inhibited by amifostine during radiation compared to nonamifostine treated.