Osteoimmunological study in the occurrence of orthodontically root resorption

正畸牙根吸收发生的骨免疫学研究

• 批准号: 19592367
• 负责人: KASAI Kazutaka
• 金额: $ 3.08万
• 依托单位: Nihon University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-19592367/
• 关键词: 重度歯根吸収; 活性型Tリンパ球; 骨免疫学; IL-17; RANKL

The increase of RANKL and IL-17 were greater in the severe root resorption group than in the non-resorption group. Further, IL-17 stimulated RANKL production from human PDL cells in time- and dose dependent manner. Immunoreaction against osteoclastogenesis (RANK, RANKL, c-fms, M-CSF, IL-1 beta, IL-6, IL-17, IL-17R, CD4) became stronger in osteoblasts, osteoclasts, odontoclasts, and fibroblasts of the periodontal ligament in root resorption area from Day 7 onwards. The IL-17/RANKL system is responsible for transducing the heavy mechanical loading signals into an odontoclastic episode in root resorption.

重度牙根吸收组RANKL和IL-17升高幅度大于非吸收组。此外，IL-17以时间和剂量依赖的方式刺激人PDL细胞产生RANKL。从第7天开始，牙根吸收区的成骨细胞、破骨细胞、破牙细胞和成纤维细胞对破骨细胞(RANK、RANKL、c-FMS、M-CSF、IL-1β、IL-6、IL-17、IL-17R、CD4)的免疫反应增强。IL-17/RANKL系统负责将机械负荷过大的信号转化为牙根吸收过程中的破牙现象。