Exploratory studies on mandibular prognathism susceptibility genes and functional analysis based on genome wide analysis

我们研究了326名东亚受试者的6种多态性基因型与头颅侧位片获得的颅面线性测量值之间的关系。P561T和C422F多态性与下颌升支高度显著相关。这些多态性几乎仅在亚洲人群中发现，在其他人群中的频率极低。在东亚人群中，GHR多态性与下颌升支高度相关，但这种相关性在其他种族中可能不同，并可能部分解释不同种族之间的颅面形态差异。

We studied the relationship between six polymorphism genotypes and craniofacial linear measurements obtained from lateral cephalograms of 326 East Asian subjects. There was a significant association between P561T and C422F polymorphisms and mandibular ramus height. These polymorphisms were found almost exclusively in the Asian population, with extremely small frequencies in other populations. GHR polymorphisms are associated with mandibular ramus height in the East Asian population, but this association is likely to be different in other ethnic groups, and may partly explain the differing craniofacial morphology seen among different ethnicities.