Functional role of inhibitory neurons in the signal processing of the trigeminal pain

我们发现GAD67-GFP敲入小鼠三叉神经尾侧亚核(Sp5C)的抑制性GABA能神经元只接受兴奋性突触后传入，并以多极型体节为特征。此外，我们还发现卡马西平的镇痛作用是由于与GABA能神经元相比，非GABA能神经元对Sp5C的抑制更大。

We found that inhibitory GABAergic neurons in the trigeminal subnucleus caudalis (Sp5C) of GAD67-GFP knock-in mouse received exclusively excitatory postsynaptic inputs, and were characterized by multipolar-shaped somata. Furthermore, we showed that an analgesic action of carbamazepine resulted from the large depression of non-GABAergic neuron in the Sp5C compared with that of GABAergic neuron.