Covalent Immobilisation of Growth Factors on Plasma Modified Titanium for Achieving Enhanced Bone Growth and Bonding in Implant Prosthetics

将生长因子共价固定在等离子体改性钛上，以增强植入假体中的骨生长和粘合

• 批准号: LP0347686
• 负责人: Em/Prof Roger Smart
• 金额: $ 18.63万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Linkage Projects
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-09-30 至 2006-09-30
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/LP0347686
• 关键词: Covalent; Immobilisation; Growth; Factors; Plasma

This project is aimed at improving the fixation of titanium implants by combining the surface technologies expertise of University of South Australia and Flinders University with TGR BioSciences's growth factors expertise. Plasma modified and hydroxyapatite-coated implant surfaces will be used for covalent immobilisation of growth factors via tethers with tailored wettability and flexibility. This innovative strategy is expected to yield high retention of growth factor bioactivity and increased bone-implant integration for long-term implant stability. Knowledge, expertise and techniques developed will help TGR BioSciences expanding its research base and business. Training of students in the emerging field of nano-biotechnology will be another major outcome.

本项目旨在结合南澳大利亚大学和弗林德斯大学的表面技术专业知识和TGR生物科学公司的生长因子专业知识，提高钛植入物的固定能力。等离子体修饰和羟基磷灰石涂层的植入物表面将通过具有定制润湿性和灵活性的系绳用于生长因子的共价固定。这种创新的策略有望产生高保留生长因子的生物活性和增加骨种植体整合长期种植体的稳定性。所开发的知识、专业知识和技术将有助于TGR生物科学公司扩大其研究基础和业务。在新兴的纳米生物技术领域培训学生将是另一个主要成果。