Effect of Oral Cryotherapy for Preventing Stomatitis, Adverse Chemotherapy

目的：探讨口腔冷冻治疗对癌症化疗患者口腔炎发生的影响。方法：采用随机交叉设计。患者(化疗期间的恶性淋巴瘤患者)被随机分为冷冻组或对照组。受试者使用SF-36QOL量表对其生活质量进行评估。医生利用NCI-CTC[国家癌症研究所-共同毒性标准]分级标准，在化疗开始前和14天后对受试者口腔炎进行评估。结果：冷冻组与对照组的口腔炎发生率无明显差异。根据SF36生活质量量表的测量，第二和第三个化疗周期之间的生活质量有所下降。结论：冷冻组和对照组口腔炎的发生率较低，可能是由于未充分考虑化疗后冷冻组的治疗方案。

Objective : To clarify the effect of oral cryotherapy on the development of stomatitis in the cancer patient who treatment with chemotherapy. Methods : Using a randomized crossover design. Patients (the malignant lymphoma patients during a chemotherapy) were randomized to the cryotherapy group or the control group. Subjects evaluate their QOL utilizing the SF-36 QOL scale. The physician evaluates subject stomatitis both before and 14 days after the initiation of chemotherapy, utilizing the NCI-CTC [National Cancer Institute-Common Toxicity Criteria] Grade Scale. Results : There was no difference in the development of stomatitis between the cryotherapy group and the control group. There was a decrease in QOL between the second and third cycles of chemotherapy as measured by the SF36 QOL scale. Conclusion : The low incidence of stomatitis in subjects during both the cryotherapy group and control group may be due to inadequate consideration of the post-chemotherapy schedule of cryotherapy.