Effect of Oral Cryotherapy for Preventing Stomatitis, Adverse Chemotherapy

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Objective : To clarify the effect of oral cryotherapy on the development of stomatitis in the cancer patient who treatment with chemotherapy. Methods : Using a randomized crossover design. Patients (the malignant lymphoma patients during a chemotherapy) were randomized to the cryotherapy group or the control group. Subjects evaluate their QOL utilizing the SF-36 QOL scale. The physician evaluates subject stomatitis both before and 14 days after the initiation of chemotherapy, utilizing the NCI-CTC [National Cancer Institute-Common Toxicity Criteria] Grade Scale. Results : There was no difference in the development of stomatitis between the cryotherapy group and the control group. There was a decrease in QOL between the second and third cycles of chemotherapy as measured by the SF36 QOL scale. Conclusion : The low incidence of stomatitis in subjects during both the cryotherapy group and control group may be due to inadequate consideration of the post-chemotherapy schedule of cryotherapy.