Role of Inflammasomes as an initial sensor for cardiovascular stress

炎症在心血管疾病的病理生理中起着关键作用。特别是，最近的研究表明，无菌炎症反应是通过称为炎性小体的多蛋白复合物介导的。本研究旨在探讨炎症小体在心血管疾病发病机制中的作用，并通过小鼠心肌缺血再灌注（I/R）损伤模型探讨调节炎症小体对心血管疾病的治疗潜力。我们的研究结果证明了炎症小体对心肌I/R后初始炎症反应的重要性，并表明炎症小体是预防心肌I/R损伤的潜在新治疗靶点。

Inflammation plays a key role in the pathophysiology of cardiovascular diseases. In particular, recent studies suggest that a sterile inflammatory response is mediated through a multiple-protein complex called the inflammasomes. The purpose of this study is to investigate the role of inflammasomes in the pathogenesis of cardiovascular diseases and explore a therapeutic potential of regulating inflammasomes for cardiovascular diseases using a murine model of myocardial ischemia-reperfusion (I/R) injury. Our results demonstrate the importance of inflammasomes for the initial inflammatory response after myocardial I/R and suggest that the inflammasome is a potential novel therapeutic target for preventing myocardial I/R injury.