Toward understanding the mechanisms for neural circuit formation and functional architecture of the zebrafish olfactory system

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To understand the mechanisms underlying neural circuit formation and functional architecture of the olfactory system, we used a model organism, zebrafish, which is amenable to forward/reverse genetics, in vivo neural activity imaging, and various olfactory behavioral analyses. As a result, we obtained several new findings including the identification of distinct types of olfactory sensory neurons responsive to different odor stimuli, the anatomical and functional dissection of olfactory neural circuitry mediating the attractive response to amino acids, and the discovery of a direct and asymmetric axon projection from the olfactory bulb to the right habenular nucleus.