Developmental neurotoxicity of environmental chemicals : Development of an evaluation method through toxicogenomic approach

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In order to develop an efficient method to evaluate developmental neurotoxicity of chemicals, we analyzed gene expression changes in the brain of rats fetally exposed to tributyl tin (TBT) or thalidomide using original oligonucleotide microarrays. About 450 developmentally regulated genes were selected experimentally, and gene-specific 45-mer oligonucletide probes were spotted onto microarrays. The results showed that sensitivity of brain regions and gene groups were significantly different between the 2 chemicals, indicating that neurotoxicity arising from 2 different mechanisms could be effectively detected and distinguished by this method.