Regulation of endosome formation and recycling by Cdk5/p35 in neurons

点击翻译按钮获取中文摘要

CIN85 is an adapter protein involved in endocytosis and AATYK1 is a Ser/Thr kinase expressed highly in neurons. We found recently that both were phosphorylated by Cdk5. We studied roles of their Cdk5 phosphorylation in neurons. AATYK1 was shown to regulate recycling endosomal trafficking and the activity was suppressed by phosphorylation with Cdk5. AATYK1 activity is involved in axonal elongation. The function of CIN85 is not known. We generated a specific antibody to investigate endogenous CIN85 localization in neurons. CIN85 was present as small particles in neuronal soma and process, which were thought to be very early endocytic structures.