Structural Interactome Studies from Computational and Bioinformatics Approaches

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For structural interactome study, which investigates the protein-protein interaction network based on their tertiary structures, we have constructed several different kinds of databases and made informatics analyses by identifying and predicting the interfaces, so that complex structural models have been predicted. In addition, for the intrinsically denatured proteins, we have successfully reproduced and analyzed their coupled folding and binding procedures as the stable states in the free energy landscapes from computational studies.