Molecular analysis of hormonal orchestration that induces various seasonal polyphenisms

本研究首先克隆并鉴定了水稻滞育激素信息素生物合成激活神经肽(Dh-PBAN)基因，编码5种Phe-X-Pro-Arg-Leu-NH2(FXPRLa)神经肽。我们发现，Orgyia DH不仅诱导胚胎滞育，而且这种神经肽还诱导季节性多表型，参与卵泡和卵巢的肥大。这是首次有研究表明神经肽在季节生殖多物性中具有多效性，从而完成季节适应。我们还表明，一个新的因素(即，水解氢神经肽)作为一个重要的诱因的季节性多发性潜在的生活史权衡。

To analyze the molecular mechanisms involved in reproductive polyphenism, including the diapause induction of Orgyia the llina, we first cloned and characterized the diapause hormone-pheromone biosynthesis activating neuropeptide(DH-PBAN) cDNA encoding the five Phe-X-Pro-Arg-Leu-NH_2(FXPRLa) neuropeptides. We revealed that not only does the Orgyia DH induce embryonic diapause, but also that this neuropeptide induces seasonal polyphenism, participating in the hypertrophy of follicles and ovaries. This is the first study showing that a neuropeptide has a pleiotropic effect in seasonal reproductive polyphenism to accomplish seasonal adaptation. We also show that a novel factor(i. e., the DH neuropeptide) acts as an important inducer of seasonal polyphenism underlying a life-history tradeoff.