Basic research on the development of novel anticancer drugs utilizing bioactive substances from insects

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The purpose of this study was to clarify the mode of action of beetle-derived antimicrobial peptides which attack some cancer cells but not normal cells. The peptides were revealed to electrostatically interact with negatively charged phosphatidylserine and disrupt the membrane of some cancer cells. On the other hand, a new compound, 1,1’-biphenyl-3,3’,4-triol was isolated and identified from a termite, Nasutitermes takasagoensis (Shiraki). This compound showed the suppressing activity of cancer cell proliferation, and the mode of action was suggested to be different from those of already-known anticancer drugs