Characterization of molecular mechanisms of bovine fat accumulation by global gene expression analysis

通过全局基因表达分析表征牛脂肪积累的分子机制

• 批准号: 20380149
• 负责人: ROH Sanggun
• 金额: $ 12.06万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20380149/
• 关键词: ウシ; 脂肪細胞; 遺伝子解析; Chemerin; Adipogenin; 脂肪組織; 網羅的解析

This study was to investigate the molecular mechanism of fat accumulation and adipogenesis by DNA chip using adipose tissues from 10- and 24-month-old Japanese Black Cattle. Several candidate genes were separated and identified from global gene expression analysis. Adipogenin, chemerin and mPARM-1 genes were confirmed to relate to lipid metabolism and adipocyte differentiation in bovine adipocytes. These results suggested that several genes were involved with adipogenesis and fat accumulation in bovine.

本研究以10月龄和24月龄日本黑牛为研究对象，利用DNA芯片技术研究脂肪积累和脂肪形成的分子机制。从全局基因表达分析中分离并鉴定了几个候选基因。脂肪素基因、chemerin基因和mPARM-1基因在牛脂肪细胞中被证实与脂代谢和脂肪细胞分化有关。这些结果表明，牛脂肪形成和脂肪积累过程中涉及到多个基因。

项目成果

Up-regulation of chemerin and chemerin receptor by TNF-α in bovine differentiated adipocytes in vitro.

体外牛分化脂肪细胞中 TNF-α 对凯莫瑞和凯莫瑞受体的上调。

• 发表时间: 2008
• 作者: Roh;S.G.;Katoh K.
• 通讯作者: Katoh K.

Chemerin, highly expressed in adipose tissues, stimulates the glycerol release in bovine differentiated adipocytes in vitro.

Chemerin 在脂肪组织中高度表达，在体外刺激牛分化脂肪细胞中甘油的释放。

• 发表时间: 2008
• 作者: Song;S.H.;Fukui;K.;Hamano;K.;Sasaki;S.;Roh;S.G.;Katoh;K.
• 通讯作者: K.

Central administration of galanin stimulates feeding behavior in chicks.

• DOI: 10.1016/j.cbpa.2008.08.001
• 发表时间: 2008-12
• 期刊: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
• 作者: T. Tachibana;Miyabi Mori;M. I. Khan;H. Ueda;K. Sugahara;K. Hiramatsu

Intensive nursing and feeding during the early growth period altered intramuscular adipogenesis in crossbred steers (Japanese Black male×Holstein female).

早期生长阶段的强化护理和喂养改变了杂交公牛（日本黑人雄性×荷斯坦雌性）的肌内脂肪形成。

• 发表时间: 2010
• 期刊: J.Anim.Vet.Adv. 9(6)
• 作者: Ebara F.;S.Inada;S.Asaoka;Y.Isozaki;A.Saito;T.Etoh;Y.Shiotsuka;T.Gotoh
• 通讯作者: T.Gotoh

Prostatic Androgen-Repressed Message-1 as a Regulator of Adipocyte Differentiation in the mouse.

前列腺雄激素抑制的 Message-1 作为小鼠脂肪细胞分化的调节剂。

• 发表时间: 2009
• 期刊: Tohoku J.of Exp.Med. 219
• 作者: Song SH;Hong YH;Sasaki S;Roh SG (Corresponding Author);Katoh K.
• 通讯作者: Katoh K.