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Characterization of molecular mechanisms of bovine fat accumulation by global gene expression analysis

Characterization of molecular mechanisms of bovine fat accumulation by global gene expression analysis
通过全局基因表达分析表征牛脂肪积累的分子机制
批准号:
20380149
负责人:
ROH Sanggun
金额:
$12.06万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
翻译
本研究以10月龄和24月龄日本黑牛的脂肪组织为材料,利用DNA芯片技术研究脂肪积累和成脂的分子机制。从全局基因表达分析中分离和鉴定了几个候选基因。脂肪生成素、趋化蛋白和mPARM-1基因被证实与牛脂肪细胞的脂代谢和脂肪细胞分化有关。这些结果表明,有几个基因与牛的脂肪生成和脂肪积累有关。
英文摘要
This study was to investigate the molecular mechanism of fat accumulation and adipogenesis by DNA chip using adipose tissues from 10- and 24-month-old Japanese Black Cattle. Several candidate genes were separated and identified from global gene expression analysis. Adipogenin, chemerin and mPARM-1 genes were confirmed to relate to lipid metabolism and adipocyte differentiation in bovine adipocytes. These results suggested that several genes were involved with adipogenesis and fat accumulation in bovine.
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会议论文
Up-regulation of chemerin and chemerin receptor by TNF-α in bovine differentiated adipocytes in vitro.
体外牛分化脂肪细胞中 TNF-α 对凯莫瑞和凯莫瑞受体的上调。
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Roh, S.G., Katoh K.]
通讯作者: Katoh K.
Chemerin, highly expressed in adipose tissues, stimulates the glycerol release in bovine differentiated adipocytes in vitro.
Chemerin 在脂肪组织中高度表达,在体外刺激牛分化脂肪细胞中甘油的释放。
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Song, S.H., Fukui, K., Hamano, K., Sasaki, S., Roh, S.G., Katoh, K.]
通讯作者: K.
DOI: 10.1016/j.cbpa.2008.08.001
发表时间: 2008-12
期刊: Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
影响因子: --
作者: [T. Tachibana;Miyabi Mori;M. I. Khan;H. Ueda;K. Sugahara;K. Hiramatsu]
通讯作者: T. Tachibana;Miyabi Mori;M. I. Khan;H. Ueda;K. Sugahara;K. Hiramatsu
Intensive nursing and feeding during the early growth period altered intramuscular adipogenesis in crossbred steers (Japanese Black male×Holstein female).
早期生长阶段的强化护理和喂养改变了杂交公牛(日本黑人雄性×荷斯坦雌性)的肌内脂肪形成。
DOI: --
发表时间: 2010
期刊: J.Anim.Vet.Adv. 9(6)
影响因子: --
作者: [Ebara F., S.Inada, S.Asaoka, Y.Isozaki, A.Saito, T.Etoh, Y.Shiotsuka, T.Gotoh]
通讯作者: T.Gotoh
20
    Analysis of new endocrine regulatory system between posterior pituitary gland and adipose-mammary gland tissues via oxytocin receptor
    • 批准号:
      23658219
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2011
    • 负责人:
      ROH Sanggun
    • 依托单位:
    海外基金