Production of gene-designed domestic animals by combination of marker assisted selection and advanced reproductive technologies

本研究的目的是通过结合标记辅助选择基因（GH，SCD和TP 53）预期更好的质量性状和先进的生殖技术，有效地生产基因设计的小牛：来自具有已知遗传组成的个体的卵母细胞和精子的体外受精，以及胚胎移植的结果。2010年秋季，将8个体外生产的胚胎移植给4个受体。每头小牛产下两个受体。2011年7月21日，一只基因设计的雄性小牛成功出生;然而，另一只是一只死胎。

The objective of the present study was efficient production of gene-designed calves by combination of marker assisted selection for genes (GH, SCD and TP53) expected better quality traits and advanced reproductive technologies: In vitro fertilization of oocytes and sperm derived from individuals having known-genetic constitution, and embryo transfer of resultants. Eight embryos derived by in vitro production were transferred to four recipients in autumn in 2010. Two recipients were delivered of each one calf. One gene-designed male calf was successfully born 21th July in 2011 ; however, other one was a still-born male calf.