Comparative analysis on metastasis-associated molecules in malignant tumors with different metastatic routes such as canine mammary cancer and osteosarcoma

采用裸鼠原位移植瘤模型和异位移植瘤模型，研究肿瘤生长和转移的差异。在犬骨肉瘤细胞-异种移植模型中，生长和转移随移植部位的不同而显著不同，在该小鼠模型中，Ezrin的表达与转移密切相关。在犬乳腺癌模型中，不同移植部位的生长和转移没有显著差异，但血管内皮生长因子和核因子κB(NF-κB)的表达与该模型的生长和转移有关。

Difference in growth and metastasis was investigated using tumor a cell linetransplanted nude mice model receiving orthotopic and ectopic xenograft. In a canine osteosarcoma cell-xenografted model, growth and metastasis were significantly different depending on the xenografted site and ezrin expression was strongly related to metastasis in this mice model. In a canine mammary cancer model, there was no significant difference in the growth and metastasis depending on the xenografted sites, however VEGF (vascular endothelial growth factor) and NF-κB (nuclear factor κB) expressions were related to growth and metastasis in this mice model.