Comparative analysis on metastasis-associated molecules in malignant tumors with different metastatic routes such as canine mammary cancer and osteosarcoma

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Difference in growth and metastasis was investigated using tumor a cell linetransplanted nude mice model receiving orthotopic and ectopic xenograft. In a canine osteosarcoma cell-xenografted model, growth and metastasis were significantly different depending on the xenografted site and ezrin expression was strongly related to metastasis in this mice model. In a canine mammary cancer model, there was no significant difference in the growth and metastasis depending on the xenografted sites, however VEGF (vascular endothelial growth factor) and NF-κB (nuclear factor κB) expressions were related to growth and metastasis in this mice model.