Comparative analysis on metastasis-associated molecules in malignant tumors with different metastatic routes such as canine mammary cancer and osteosarcoma

犬乳腺癌、骨肉瘤等不同转移途径恶性肿瘤转移相关分子的比较分析

• 批准号: 20380170
• 负责人: SASAKI NOBUO
• 金额: $ 12.4万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20380170/
• 关键词: 犬骨肉腫; 犬乳癌; 細胞株; ヌードマウス; 移植部位; 増殖; 肺転移; 転移経路; ヌードマウスモデル; NF-kB; VEGF; NF-κB; クローン細胞株; ezrin; 低酸素因子

Difference in growth and metastasis was investigated using tumor a cell linetransplanted nude mice model receiving orthotopic and ectopic xenograft. In a canine osteosarcoma cell-xenografted model, growth and metastasis were significantly different depending on the xenografted site and ezrin expression was strongly related to metastasis in this mice model. In a canine mammary cancer model, there was no significant difference in the growth and metastasis depending on the xenografted sites, however VEGF (vascular endothelial growth factor) and NF-κB (nuclear factor κB) expressions were related to growth and metastasis in this mice model.

采用裸鼠原位和异位移植瘤模型，观察肿瘤生长和转移的差异。在犬骨肉瘤细胞异种移植模型中，生长和转移根据异种移植部位而显著不同，并且在该小鼠模型中ezrin表达与转移密切相关。在犬乳腺癌模型中，不同部位移植瘤的生长和转移无显著差异，但VEGF（血管内皮生长因子）和NF-κB（核因子κB）表达与该小鼠模型的生长和转移相关。

项目成果

Effects of curucumin on growth and metastasis of canine MGT in a nude mice xenograft model.

姜黄素对裸鼠异种移植模型中犬 MGT 生长和转移的影响。

• 发表时间: 2010
• 作者: Mkaouar;L.;et al.
• 通讯作者: et al.

イヌ骨肉腫細胞株におけるRANK/RANKL/OPG発現と細胞移植モデルにおける骨病変

RANK/RANKL/OPG在犬骨肉瘤细胞系和细胞移植模型骨病变中的表达

• 发表时间: 2010
• 作者: 上田綾子;他
• 通讯作者: 他

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Effects of curucumin on growth and metastasis of canine MGT in a nude mice xenogr

姜黄素对裸鼠异种犬MGT生长和转移的影响

• 发表时间: 2010
• 作者: Lobna Mkaouar;et al.
• 通讯作者: et al.

Effect of transplantation sites on tumor growth, pulmonary metastasis and ezrin expression in canine osteosarcoma xenograft and clinical patients.

移植部位对犬骨肉瘤异种移植物和临床患者肿瘤生长、肺转移和埃兹蛋白表达的影响。

• 发表时间: 2010
• 作者: Jaroensong;T.;et al
• 通讯作者: et al