Elucidation of long-term influence to a central nervous system by an organic arsenic compound

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This research makes it clear that in the peroral administration of diphenylarsinic acid (DPAA) to Macaca fascicularis (crab-eating macaques), DPAA accumulates in the central nervous system over a long period of time. Using brain PET to study the effects of DPAA on cerebral blood flow and brain glucose metabolism, we found that it had affected the cerebellum, brainstem, and occipital lobes. No pathological changes were seen, however, in the central nerve tissue. In people exposed to DPAA, symptoms present themselves in the brainstem, the cerebellum, and the tempero-occipital lobes, and decreased blood flow and brain glucose metabolism to these areas is also seen. We believe that we were able to reproduce this influence of DPAA on the central nervous system in Macaca fascicularis, as well.