Study on roles of a novel NADPH oxidase isoform in the development of lifestyle related diseases
Study on roles of a novel NADPH oxidase isoform in the development of lifestyle related diseases
批准号:
20390071
负责人:
YABE Chihiro
金额:
$12.98万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Induction of hyperglycemia with streptozotocin up-regulated the expression of NOX1, a novel isoform of superoxide-generating NADPH oxidase in the kidney. NOX1 derived ROS were shown to increase oxidative stress and to activate p38 MAPK, thereby stimulating renal redox-sensitive signaling under diabetic conditions.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Renal redox-sensitive signaling in type 1 diabetes is suppressed in Nox1-deficient mice.
Nox1 缺陷小鼠中 1 型糖尿病中的肾脏氧化还原敏感信号传导受到抑制。
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Zhu K, Matsumoto M, Iwata K, Yabe-Nishimura C.]
通讯作者:
Yabe-Nishimura C.
DOI:
10.1016/j.bbrc.2008.07.027
发表时间:
2008-09-19
期刊:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子:
3.1
作者:
[Cevik, Muhammer Ozgur, Katsuyama, Masato, Yabe-Nishimura, Chihiro]
通讯作者:
Yabe-Nishimura, Chihiro
糖尿病性腎症モデルにおける活性酸素産生酵素Nox1の解析
糖尿病肾病模型中活性氧产生酶Nox1的分析
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[筧朋子, 岩田和実, Taye Ashraf, 松野邦晴, 矢部千尋]
通讯作者:
矢部千尋
A study on the role of NOX1/NADPH oxidase in cardiac arrhythmia
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批准号:23659140
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2011
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负责人:YABE Chihiro
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依托单位:
Vascular remodeling in Nox1/NADPH oxidase deficient mice
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批准号:17590225
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2005
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负责人:YABE Chihiro
-
依托单位:
Paradoxical roles of the aldehyde-metabolizing enzyme, aldose reductase in cardioprotection
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批准号:15590470
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2003
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负责人:YABE Chihiro
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依托单位: