Study on roles of a novel NADPH oxidase isoform in the development of lifestyle related diseases

新型 NADPH 氧化酶亚型在生活方式相关疾病发生中的作用研究

• 批准号: 20390071
• 负责人: YABE Chihiro
• 金额: $ 12.98万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390071/
• 关键词: 糖尿病; 循環器・高血圧; シグナル伝達; 薬理学

Induction of hyperglycemia with streptozotocin up-regulated the expression of NOX1, a novel isoform of superoxide-generating NADPH oxidase in the kidney. NOX1 derived ROS were shown to increase oxidative stress and to activate p38 MAPK, thereby stimulating renal redox-sensitive signaling under diabetic conditions.

用链脲佐菌素诱导高血糖可上调NOX1的表达，NOX1是肾脏中产生超氧化物的NADPH氧化酶的一种新亚型。NOX1衍生的ROS显示出增加氧化应激并激活p38 MAPK，从而在糖尿病条件下刺激肾氧化还原敏感性信号传导。

项目成果

Renal redox-sensitive signaling in type 1 diabetes is suppressed in Nox1-deficient mice.

Nox1 缺陷小鼠中 1 型糖尿病中的肾脏氧化还原敏感信号传导受到抑制。

• 发表时间: 2011
• 作者: Zhu K;Matsumoto M;Iwata K;Yabe-Nishimura C.
• 通讯作者: Yabe-Nishimura C.

The AP-1 site is essential for the promoter activity of NOX1/NADPH oxidase, a vascular superoxide-producing enzyme: Possible involvement of the ERK1/2-JunB pathway

• DOI: 10.1016/j.bbrc.2008.07.027
• 发表时间: 2008-09-19
• 期刊: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
• 影响因子: 3.1
• 作者: Cevik, Muhammer Ozgur;Katsuyama, Masato;Yabe-Nishimura, Chihiro
• 通讯作者: Yabe-Nishimura, Chihiro

糖尿病性腎症モデルにおける活性酸素産生酵素Nox1の解析

糖尿病肾病模型中活性氧产生酶Nox1的分析

• 发表时间: 2008
• 作者: 筧朋子;岩田和実;Taye Ashraf;松野邦晴;矢部千尋
• 通讯作者: 矢部千尋