Systems biological analysis of dynamic regulation of stem cells and development by growth factors

我们旨在通过使用新的生物信息学来阐明生长因子如何调节组织类型特定干细胞的自我更新活性的分子机制。因此，我们确定Hes1是神经干细胞自我更新的关键分子靶点，FRS2α-Shp2-Tbx2通路是心脏前体细胞发育的关键途径。此外，我们发现NFkB是哺乳动物干细胞和乳腺癌干细胞自我更新的关键分子靶点。

We aimed to clarify molecular mechanisms how growth factors regulate self-renewing activity of tissue type specific stem cells by using novel bioinfomatics. As a result, we identified Hes1 as a key molecular target of self-renewal of neural stem cells and FRS2alpha-Shp2-Tbx2 pathway as a key pathway for development of cardiac progenitor cells. Moreover, we identified NFkB as a key molecular target for self-renewing mammalian stem cells as well as breast cancer stem cells.