Roles of novel target genes of Cdx1/2 in differentiation and transformation of intestinal epithelial cells.
Roles of novel target genes of Cdx1/2 in differentiation and transformation of intestinal epithelial cells.
批准号:
20390110
负责人:
AOKI Masahiro
金额:
$12.56万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Expression of the Slc5a8 gene encoding a short-chain fatty acid transporter was positively regulated by Cdx1/2 in vivo, and its level was reduced in the colonic polyps of Apc mutant mice, accompanied by decreased expression of Cdx2. Plekhg1 was shown to be a direct target gene of Cdx1/2. Plekhg1 was involved in E-cadherin-mediated cell-cell adhesion, and bound to 14-3-3 only when phosphorylated at serine 611.
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DOI:
10.1053/j.gastro.2009.04.059
发表时间:
2009-08-01
期刊:
GASTROENTEROLOGY
影响因子:
29.4
作者:
[Arimura, Sumimasa, Matsunaga, Akihiro, Taketo, Makoto M.]
通讯作者:
Taketo, Makoto M.
CDX Transcription Factors Positively Regulate Expression of Solute Carrier Family 5
CDX 转录因子正向调节溶质载体家族 5 的表达
DOI:
--
发表时间:
2010
期刊:
Member 8 in the Colonic Epithelium. Gastroenterology 138
影响因子:
--
作者:
[Kakizaki F, Aoki K, Miyoshi H, Carrasco N, Aoki M, Taketo MM]
通讯作者:
Taketo MM
DOI:
10.1016/j.ccr.2010.11.008
发表时间:
2011-01-18
期刊:
CANCER CELL
影响因子:
50.3
作者:
[Sonoshita, Masahiro, Aoki, Masahiro, Taketo, Makoto Mark]
通讯作者:
Taketo, Makoto Mark
Activated macrophages promote Wnt signalling through tumour ecrosis factor-alpha in gastric tumour cells.
激活的巨噬细胞通过胃肿瘤细胞中的肿瘤坏死因子-α 促进 Wnt 信号传导。
DOI:
--
发表时间:
2008
期刊:
Embo J 27
影响因子:
--
作者:
[Oguma K, Oshima H, Aoki M, Uchio R, Naka K, Nakamura S, Hirao A., Saya H, Taketo MM, Oshima M]
通讯作者:
Oshima M
ヘッジホッグ経路シグナル伝達分子SmoothenedによるWntシグナル伝達経路を介した腸管腫瘍形成の促進
Hedgehog通路信号分子Smoothened通过Wnt信号通路促进肠道肿瘤发生
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Okazaki Y, Matsukawa A., 有村純暢]
通讯作者:
有村純暢
共 25 条
Molecular mechanism of involvement of homeobox transcription factors Cdx2 and Cdxl in intestinal tumors
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批准号:17390113
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.16万
-
财政年份:2005
-
负责人:AOKI Masahiro
-
依托单位:
海外基金