Molecular basis of immune evasion of malaria parasites

疟原虫免疫逃避的分子基础

• 批准号: 20390121
• 负责人: HISAEDA Hajime
• 金额: $ 12.73万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390121/
• 关键词: マラリア; 制御性T細胞; TLR9; 赤血球; CD8T細胞; 防御免疫; 免疫回避; 腸管寄生性蠕虫; 病原性; 寄生適応; マラリア原虫; 樹状細胞

Mechanisms underlying immune evasion due to activation of regulatory T cells during blood-stage malaria have been carefully analyzed. Stimulation of dendritic cells with parasitized red blood cells through TLR9 resulted in activation of regulatory T cells. Furthermore, mice deficient in TLR9 were partially resistant to lethal malaria because of a failure of activating regulatory T cells. It was suggested that hemozoin, malaria pigment, is involved in activation of regulatory T cells as TLR9 ligand. We also analyzed "suppressed" protective immunity to malaria, and found protective roles of CD8 T cells previously supposed to be unlike to contribute to protection to blood-stage malaria.

由于调节性T细胞在血液期疟疾期间的激活，免疫逃避的潜在机制已经被仔细分析。通过TLR9用寄生的红细胞刺激树突状细胞导致调节性T细胞的活化。此外，缺乏TLR9的小鼠对致命性疟疾具有部分抗性，因为无法激活调节性T细胞。研究表明疟原虫色素作为TLR9配体参与调节性T细胞的活化。我们还分析了对疟疾的“抑制”保护性免疫，发现CD8 T细胞的保护作用与以前认为的对血液期疟疾的保护作用不同。

项目成果

Involvement of CD8+ T cells in protective immunity against murine blood-stage infection with Plasmodium yoelii 17XL strain

• DOI: 10.1002/eji.200939525
• 发表时间: 2010-04-01
• 期刊: EUROPEAN JOURNAL OF IMMUNOLOGY
• 影响因子: 5.4
• 作者: Imai, Takashi;Shen, Jianying;Himeno, Kunisuke
• 通讯作者: Himeno, Kunisuke

Protection exerted by CD8^+ T cells against murine blood-stage malaria

CD8^ T 细胞对鼠血期疟疾的保护作用

• 发表时间: 2010
• 作者: 黒田誠;野崎智義;Hisaeda H;Tomita K;Hisaeda H.
• 通讯作者: Hisaeda H.

Concurrent infection with Heligmosomoides polygyrus modulates murine host response against Plasmodium berghei ANKA

Heligmosomoides polygyrus 同时感染可调节小鼠宿主对伯氏疟原虫 ANKA 的反应

• 发表时间: 2008
• 期刊: American Journal of Tropical Medicine and Hygiene 79
• 作者: Tetsutani K.;et.al.
• 通讯作者: et.al.

Malaria parasites require Toll-like receptor 9 signaling for immune evasion by acrivating regulatory Tcells.

疟疾寄生虫需要 Toll 样受体 9 信号传导，通过激活调节性 T 细胞来逃避免疫。

• 发表时间: 2008
• 作者: Tanaka M.;Sakurai T.;Yokoyama N.;Inoue N.;Kawazu S.;小野江和則;Hisaeda H
• 通讯作者: Hisaeda H

Malaria parasites require TLR9 signaling for immune evasion by activating regulatory T cells

• DOI: 10.4049/jimmunol.180.4.2496
• 发表时间: 2008-02-15
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Hisaeda, Hajime;Tetsutani, Kohhei;Himeno, Kunisuke
• 通讯作者: Himeno, Kunisuke