Animal model for dystrophic epidermolysis bullosa and acquired epidermolysis bullosa using genetically engineered mice of type VII collagen
使用VII型胶原基因工程小鼠建立营养不良性大疱性表皮松解症和获得性大疱性表皮松解症动物模型
基本信息
- 批准号:20390305
- 负责人:
- 金额:$ 11.9万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2008
- 资助国家:日本
- 起止时间:2008 至 2010
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Type VII collagen is a structural protein within basement membrane zone and its gene defect leads to dystrophic epidermolysis bullosa. Also generation of autoantibody against type Vii collagen causes acquired epidermolysis bullosa. Thus, type VII collagen is a major protein in the field of dermatology. The purposes of this study are to establish models of those type VII collagen related diseases and make great contributions for disclosing disease mechanisms and development of new effective treatments using genetically engineered mice. In this study we could generate model mouse of dystrophic epidermolysis which can survive for long time. However, we could not detect auto antibody against type VII collagen in the model mice for acquired epidermolysis. Furthermore, we performed mutation analysis of patients with epidermolysis bullosa.
VII型胶原是基底膜带内的结构蛋白,其基因缺陷导致营养不良性大疱性表皮病。另外,产生抗VII型胶原的自身抗体可导致获得性大疱性表皮病。因此,VII型胶原蛋白是皮肤病学领域中的主要蛋白质。本研究的目的是建立VII型胶原相关疾病的动物模型,为揭示疾病的发病机制和利用基因工程小鼠开发新的有效治疗方法做出贡献。本研究可建立长期存活的营养不良性表皮细胞瘤模型小鼠。但在获得性表皮增生模型小鼠中未检测到抗VII型胶原自身抗体。此外,我们还对大疱性表皮病患者进行了突变分析。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Hair Follicle Stem Cells Provide a Functional Niche for Melanocyte Stem Cells
- DOI:10.1016/j.stem.2010.11.029
- 发表时间:2011-02-04
- 期刊:
- 影响因子:23.9
- 作者:Tanimura, Shintaro;Tadokoro, Yuko;Nishimura, Emi K.
- 通讯作者:Nishimura, Emi K.
Disseminated lupus vulgaris diagnosed more than 63 years after onset due to early misdiagnosis as a port-wine stain.
由于早期误诊为鲜红斑痣,播散性寻常狼疮在发病 63 年多后才被诊断出来。
- DOI:
- 发表时间:2010
- 期刊:
- 影响因子:0
- 作者:Takeuchi S;Nakano H;Daiki R;Akasaka E;Nishizawa A;Matsuzaki Y;Sawamura D.
- 通讯作者:Sawamura D.
A Severe and Refractory Case of Anti-p200 Pemphigoid Resulting in Multiple Skin Ulcers and Scar Formation
- DOI:10.1159/000182268
- 发表时间:2009-01-01
- 期刊:
- 影响因子:3.4
- 作者:Goto-Ohguchi, Y.;Nishie, W.;Shimizu, H.
- 通讯作者:Shimizu, H.
Response of Intractable Skin Ulcers in Recessive Dystrophic Epidermolysis Bullosa Patients to an Allogeneic Cultured Dermal Substitute
- DOI:10.2340/00015555-0776
- 发表时间:2010-01-01
- 期刊:
- 影响因子:3.6
- 作者:Natsuga, Ken;Sawamura, Daisuke;Shimizu, Hiroshi
- 通讯作者:Shimizu, Hiroshi
A linear basal cell carcinoma undergoing spontaneous regression.
正在自发消退的线性基底细胞癌。
- DOI:
- 发表时间:2009
- 期刊:
- 影响因子:0
- 作者:Takiyoshi N;Nakano H;Kaneko T;Aizu T;Nakajima K;Akasaka E;Rokunohe D;Sawamura D.
- 通讯作者:Sawamura D.
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
SAWAMURA Daisuke其他文献
Characterization of Melanin Radicals in Paraffin-embedded Malignant Melanoma and Nevus Pigmentosus Using X-band EPR and EPR Imaging
使用 X 波段 EPR 和 EPR 成像表征石蜡包埋的恶性黑色素瘤和色素痣中的黑色素自由基
- DOI:
10.2116/analsci.33.1357 - 发表时间:
2017 - 期刊:
- 影响因子:1.6
- 作者:
NAKAGAWA Kouichi;MINAKAWA Satoko;SAWAMURA Daisuke;HARA Hideyuki - 通讯作者:
HARA Hideyuki
SAWAMURA Daisuke的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('SAWAMURA Daisuke', 18)}}的其他基金
Immunochromatographic method using the salive for rapid diagnosis of bullous pemhigoid
唾液免疫层析法快速诊断大疱性类天疱疮
- 批准号:
16K15541 - 财政年份:2016
- 资助金额:
$ 11.9万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Induction of aoutoantibodies to BP230 and analysis of new function of BP230 using gene-engineered mouse
利用基因工程小鼠诱导BP230自身抗体并分析BP230的新功能
- 批准号:
26293254 - 财政年份:2014
- 资助金额:
$ 11.9万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Analysis of molecular mechanisms switching from TRPV3 gene abnormalities to palmoplantar keratoderma.
TRPV3基因异常转变为掌跖角化症的分子机制分析。
- 批准号:
25670497 - 财政年份:2013
- 资助金额:
$ 11.9万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Establishment of method using spin labeling that evaluates function and structure of lipids between corneal layers.
建立使用自旋标记评估角膜层之间脂质的功能和结构的方法。
- 批准号:
24659518 - 财政年份:2012
- 资助金额:
$ 11.9万 - 项目类别:
Grant-in-Aid for Challenging Exploratory Research
Development of a new murine system to degrade target proteins rapidly
开发一种新的小鼠系统来快速降解目标蛋白
- 批准号:
23390279 - 财政年份:2011
- 资助金额:
$ 11.9万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Pathogenecity of autoantibody in bullous pemphigoid and development of epitope-decoy therapy
大疱性类天疱疮自身抗体的致病性及表位诱饵疗法的进展
- 批准号:
18390309 - 财政年份:2006
- 资助金额:
$ 11.9万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Establishment of a system in which type VII collagen and laminin 5 or their genes are continuously delivered from the dermal side to the basement membrane zone
建立将VII型胶原蛋白和层粘连蛋白5或其基因从真皮侧连续输送至基底膜区的系统
- 批准号:
15390337 - 财政年份:2003
- 资助金额:
$ 11.9万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Fundamental study of gene therapy for epidermolysis bullosa : Development of gene therapy targeting keratinocyte
大疱性表皮松解症基因治疗的基础研究:针对角质形成细胞的基因治疗的开发
- 批准号:
08670941 - 财政年份:1996
- 资助金额:
$ 11.9万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Characterization of 5 prime flanking region of 230 kDa bullous pemphigoid antigen gene
230 kDa 大疱性类天疱疮抗原基因 5 主要侧翼区域的表征
- 批准号:
05670718 - 财政年份:1993
- 资助金额:
$ 11.9万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)