Molecular imaging for dynamic analysis of cancer pathological states : Toward clinical molecular imaging

在这项研究中，我们利用分子成像技术来可视化肿瘤的增殖和缺氧，并在动物模型和临床环境中展示了这种技术在分析肿瘤的病理状态和对分子靶向/放射治疗的反应方面的有效性。我们还在动物模型中展示了我们的新候选化合物用于血管生成成像的潜力和安全性。本研究结果可为利用分子成像技术在分子/细胞水平上显示肿瘤病理状态的变化，开发新的诊断和治疗策略提供重要依据。

In the present study, we utilized molecular imaging technology that visualized tumor proliferation and hypoxia, and demonstrated the usefulness in the analyses of tumor pathological states and response to molecular-targeted/radiation therapies, in animal models and clinical settings. We also demonstrated, in animal models, potentials and safety profiles of our novel candidate compound for angiogenesis imaging. The present results could provide important evidences to develop novel diagnosis and treatment strategy taking advantages of molecular imaging technology that visualizes alteration in tumor pathological states at molecular/cellular levels.