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Radiobiological study of proton beams for optimization of therapeutic effects on brain tumors

Radiobiological study of proton beams for optimization of therapeutic effects on brain tumors
质子束放射生物学研究优化脑肿瘤治疗效果
批准号:
20390323
负责人:
TSUBOI Koji
金额:
$11.23万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
In order to optimize the effects of proton beams radiotherapy for brain tumors, some uncertainties in the biological effects of proton beams were resolved in this study. First, characteristics of proton beams in DNA base damage and strand breaks were clarified compared to those of x-rays. Second, RBE values of proton beams to x-rays were measured in different endpoints. In addition, cancer-stemness in isolated radioresistant clones of brain tumor cells was demonstrated, indicating that population of cancer-stem like cells were enriched in survivors after irradiation.
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会议论文
陽子線と治療用X線により生成されるDNA二本鎖切断アポトーシスの定量的解析
质子束和治疗 X 射线产生的 DNA 双链断裂的定量分析
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [ゲレルチュルン アリウンゲレル, 洪正善, 盛武敬, 栄武二, 坪井康次]
通讯作者: 坪井康次
DOI: 10.3109/09553002.2010.518201
发表时间: 2011-01-01
期刊: INTERNATIONAL JOURNAL OF RADIATION BIOLOGY
影响因子: 2.6
作者: [Gerelchuluun, Ariungerel, Hong, Zhengshan, Tsuboi, Koji]
通讯作者: Tsuboi, Koji
陽子線治療・monotherapyから combined therapy
从质子治疗/单一治疗到联合治疗
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [中川恵一, 山下英臣, 坪井康次]
通讯作者: 坪井康次
悪性脳腫瘍に対する陽子線治療
质子束治疗恶性脑肿瘤
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Y. Hata, S. Yamaguchi, S. Kobashi, K. Oe, 西村恒彦, 坪井康次]
通讯作者: 坪井康次
40
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