Basic Comparison of Biological Effects between Protons and Carbon-Ions

质子与碳离子生物学效应的基本比较

• 批准号: 20390327
• 负责人: HISHIKAWA Yoshio
• 金额: $ 11.9万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390327/
• 关键词: 癌; 粒子線治療; 陽子線; 炭素線; 生物学的効果; 細胞老化; 活性酸素種

Particle therapy using protons or carbon-ions showed higher effectiveness than conventional X-ray therapy on basic research basis. A new finding was obtained that generation of reactive oxygen species (ROS), which plays an important role in biological effects of radiation, was not temporary but continuous after irradiation. It was also found that continuous suppression of ROS by N-acetylcysteine (NAC) lead to increased cell survival after irradiation. NAC could be used as a radioprotective agent in clinical settings.

在基础研究的基础上，质子或碳离子粒子治疗比常规x射线治疗更有效。新发现在辐射生物效应中起重要作用的活性氧（ROS）在辐照后的生成不是暂时的，而是持续的。研究还发现，n -乙酰半胱氨酸（NAC）持续抑制ROS导致辐照后细胞存活增加。NAC可作为一种放射性防护剂应用于临床。

项目成果

Particle radiotherapy Using Protons or Carbon Ions for Adenoid Cystic Carcinoma of the Head and Neck

使用质子或碳离子的粒子放射治疗头颈腺样囊性癌

• 发表时间: 2010
• 作者: Y.Demizu;K.Terashima;M.Mima;O.Fujii;Y.Niwa;K.Morimoto;D.Miyawaki;R.Sasaki;Y.Hishikawa;M.Abe;M.Murakami
• 通讯作者: M.Murakami

Difference of cell biological effects in cancer cell lines irradiated by X-ray or particle beams

X射线或粒子束照射癌细胞系细胞生物学效应的差异

• 发表时间: 2009
• 作者: T.Maeda;M.Murakami;Y.Demizu;Y.Hishikawa;M.Abe
• 通讯作者: M.Abe