Establishment of minimally invasive cell therapy for diabetes by improving the outcome of pancreatic islet transplantation

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In the present study, we have clarified that brain death in combination with warm ischemic stress during isolation procedures induces a high expression of inflammatory mediators in isolated islets. We also found that C5a inhibitory peptide attenuates cross-talk between the complement and coagulation cascades through suppressing up-regulation of tissue factor expression on leukocytes in recipient livers, a process leading to improvement in islet engraftment. This was a new concept to improve the outcome of islet transplantation. We also showed that isoflurane and short-term fasting combined with insulin treatment could be a promising regimen for improving islet engraftment in the liver.