Creation of molecular therapy for gastrointestinal cancer using inhibition of intra cellular molecular transport and regulation of epigenetics

利用细胞内分子转运的抑制和表观遗传学的调节来创建胃肠道癌症的分子疗法

• 批准号: 20390351
• 负责人: MATSUBARA Hisahiro
• 金额: $ 12.4万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20390351/
• 关键词: 消化器癌; 細胞内分子移動; エピジェネティクス; 分子治療; micro RNA; エピジネティクス

In order to create new molecular therapy for gastrointestinal cancer, we have planed the regulation of gene transduction, translation and protein synthesis. Furthermore, we have tried inhibition of intracellular molecular transport for the same purpose. We found that new molecule which inhibit enzyme for genetic expression have good efficieny for gene therapy. And this molecule was revealed anti-tumor action. The regulation of molecular transportation between nuclear and cytoplasm have induced cell death. These new molecules are important seeds for translational research and extremely useful for new development of molecular therapy for gastrointestinal cancer.

从基因转导、翻译和蛋白质合成的调控方面进行了研究，以期为胃肠道肿瘤的分子治疗开辟新的途径。此外，我们还尝试了抑制细胞内的分子转运，以达到同样的目的。我们发现抑制基因表达酶的新分子对基因治疗有很好的效果。并且该分子具有抗肿瘤作用。细胞核与细胞质之间分子运输的调节导致细胞死亡。这些新分子是转化研究的重要种子，对胃肠道肿瘤分子治疗的新发展极为有用。

项目成果

COX2 Expression Predicts Resistance to Chemoradiotherapy in Esophageal Squamous Cell Carcinoma

• DOI: 10.1245/s10434-011-1645-z
• 发表时间: 2011-10-01
• 期刊: ANNALS OF SURGICAL ONCOLOGY
• 影响因子: 3.7
• 作者: Akutsu, Yasunori;Hanari, Naoyuki;Matsubara, Hisahiro
• 通讯作者: Matsubara, Hisahiro

An alternative splicing isoform of eukaryotic initiation factor 4H promotes tumorigenesis in vivo and is a potential therapeutic target for human cancer

• DOI: 10.1002/ijc.25419
• 发表时间: 2011-03
• 期刊: International Journal of Cancer
• 影响因子: 6.4
• 作者: Di Wu;K. Matsushita;H. Matsubara;F. Nomura;T. Tomonaga

miR-145, miR-133a and miR-133b: tumor-suppressive miRNAs target FSCN1 in esophageal squamous cell carcinoma

• DOI: 10.1002/ijc.25284
• 发表时间: 2010-12-15
• 期刊: INTERNATIONAL JOURNAL OF CANCER
• 影响因子: 6.4
• 作者: Kano, Masayuki;Seki, Naohiko;Matsubara, Hisahiro
• 通讯作者: Matsubara, Hisahiro

Effects of carbon-ion radiotherapy combined with a novel histone deacetylase inhibitor, cyclic hydroxamic-acid-containing peptide 31 in human esophageal squamous cell carcinoma.

• 发表时间: 2009-11
• 期刊: Anticancer research
• 影响因子: 2
• 作者: M. Kano;S. Yamada;Isamu Hoshino;Kentaro Murakami;Y. Akutsu;H. Sakata;T. Nishimori;A. Usui;Y. Miyazawa;T. Kamada;H. Tsujii;H. Matsubara

食道癌の外科治療と新規治療法の現況

食管癌手术治疗现状及新治疗方法

• 发表时间: 2008
• 作者: 甲斐 昌也;中村 雅史;他;阿部豊文,李小康,畑山直之,角田洋一,蔦原宏一,奥見雅由,矢澤浩治,貝森淳哉,高原史郎;田原裕之;松原久裕
• 通讯作者: 松原久裕