Analysis of type V/XI collagen gene regulation and its function in bone, cartilage, muscle and dentin.

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Type V/XI collagen is essential for fibrogenesis. It consists of six α chains, of which expression are restrictedly regulated temporally and spaciously. In present project, we clarified the basal promoter region of α1(V) and α3(V) collagen genes in osteoblastic cells and α2(XI) collagen gene in odontoblastic cells. We also identified the binding site of osteoblast differential factor, Sp7/Osterix, in the promoter of α1(V) and α3(V) collagen genes. Furthermore, we showed the expression pattern of the α chains using wound healing model.