Elucidation of regulatory and repair mechanisms of brain lesion mediated by l ipid metabolism in glial cells.

在实验性脱髓鞘、缺血和神经退行性变的动物模型中，我们检测了在神经系统神经胶质细胞和神经细胞中表达的三种脂代谢相关酶：Liididosin、羊毛甾醇14α去甲基酶、和硬脂酰辅酶A去饱和酶的表达变化。我们的研究结果表明，这些酶参与了脑损伤的发展及其恢复过程的调节，如重新髓鞘形成、脑缺血恢复和神经退行性变的早期反应。

We examined the expression changes of three kinds of lipid metabolism-related enzymes, lipidosin、lanosterol 14α-demethylase、and stearoyl-CoA desaturase, which are expressed in glial and neuronal cells in the nervous system, in the animal model of experimental demyelination, ischemia and neurodegeneration. We obtained findings that suggest involvements of these enzymes in the regulation of the development of brain lesions and the recovery processes from them such as remyelination, recovery from brain ischemia and early responses in neurodegeneration.