Regulation of the maturation of cerebellar synapses by PKN
Regulation of the maturation of cerebellar synapses by PKN
批准号:
20500354
负责人:
YASUDA Hiroki
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
I investigated the role of PKN1 in synaptic transmission and synaptic plasticity in the central nervous system electrophysiologically using PKN1a knockout (KO) mice. I found LTD was enhanced and heterosynaptic LTD was induced in the hippocampus of developing PKN1a KO mice and synaptic transmission was more immature. I concluded that PKN1 is promoting synaptic maturation by inhibiting LTD during development.
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DOI:
10.1523/jneurosci.0899-08.2008
发表时间:
2008-07-09
期刊:
JOURNAL OF NEUROSCIENCE
影响因子:
5.3
作者:
[Huang, Yan, Yasuda, Hiroki, Tsumoto, Tadaharu]
通讯作者:
Tsumoto, Tadaharu
Neuron-specific drebrin isoform is necessary for hippocampus-dependent learning in adulthood but not in young age of mice
神经元特异性的drebrin亚型对于成年期海马依赖性学习是必需的,但对于小鼠的年轻期则不然
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Hirano Y, Ishiguro N, Sokabe M, Takigawa M, Naruse K, Kojima N]
通讯作者:
Kojima N
Regulation of excitability and plasticity by endocannabinoids and PKA in developing hippocampus
内源性大麻素和 PKA 对发育中海马的兴奋性和可塑性的调节
DOI:
--
发表时间:
2008
期刊:
Proc Natl Acad Sci (USA)
影响因子:
--
作者:
[安田浩樹, Yan Huang, Tadaharu Tsumoto]
通讯作者:
Tadaharu Tsumoto
DOI:
10.1016/j.neulet.2009.12.078
发表时间:
2010-02
期刊:
Neuroscience Letters
影响因子:
2.5
作者:
[Yuma Sonoda;H. Mukai;K. Matsuo;Mikiko Takahashi;Y. Ono;K. Maeda;H. Akiyama;T. Kawamata]
通讯作者:
Yuma Sonoda;H. Mukai;K. Matsuo;Mikiko Takahashi;Y. Ono;K. Maeda;H. Akiyama;T. Kawamata
A peptidyl–prolyl isomerase, FKBP12, accumulates in Alzheimer neurofibrillary tangles
肽基-脯氨酰异构酶 FKBP12 在阿尔茨海默病神经原纤维缠结中积聚
DOI:
--
发表时间:
2009
期刊:
Neuroscience Letters
影响因子:
2.5
作者:
[H. Sugata, K. Matsuo, Taisuke Nakagawa, Mikiko Takahashi, H. Mukai, Y. Ono, K. Maeda, H. Akiyama, T. Kawamata]
通讯作者:
T. Kawamata
PKN1 regulates metaplasticity in hippocampus
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批准号:23500461
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.33万
-
财政年份:2011
-
负责人:YASUDA Hiroki
-
依托单位:
Analysis of the mechanisms of the synapse formation of newborn neurons by developing mice with channelrhodopsin-2 only in newborn neuron in the dentate gyrus.
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批准号:21200016
-
项目类别:Grant-in-Aid for Scientific Research on Innovative Areas (Research a proposed research project)
-
资助金额:$19.8万
-
财政年份:2009
-
负责人:YASUDA Hiroki
-
依托单位:
海外基金