Mechanisms of endocannabinoid-mediated synaptic plasticity

点击翻译按钮获取中文摘要

In the present study, we investigated the conditions inducing long-lasting endocannabinoid release, which is required for endocannabinoid-mediated long-term depression. We demonstrated that protease-activated receptor-1 (PAR1), which can be activated persistently by proteases, can induce endocannabinoid release when activated. We observed that the activation of group 1 metabotropic glutamate receptors or M_1/M_3 muscarinic receptors occasionally induced long-lasting endocannabinid release, which could not be attributed to long-lasting enhancement of PLCβ.