Elucidation of regulatory mechanism of AMPA-receptor's trafficking by visualization of its intracellular pool.
Elucidation of regulatory mechanism of AMPA-receptor's trafficking by visualization of its intracellular pool.
批准号:
20500363
负责人:
YAMAGUCHI Kazuhiko
金额:
$2.83万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Long-term depression (LTD) of synaptic efficacy in the cerebellar Purkinje cell provides an underlying mechanism for motor learning. We analyzed distribution of intracellular pool of AMPA-receptors (AMPA-Rs) by means of double-expression of Green fluorescent protein (GFP) and Red fluorescent protein (mCherry)-tagged AMPA-Rs in cultured Purkinje cell. We found that LTD-stimulation caused translocation of intracellular pool of AMPA-Rs from the spine to the shaft of dendrite, but it caused no change in shape of the spine.
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小脳プルキンエ細胞樹状突起スパインにおけるAMPA受容体分布変化と長期抑圧
小脑浦肯野细胞树突棘 AMPA 受体分布变化和长期抑制
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[山口和彦, 清水知佳, 佐藤友美, 古市貞一, 伊藤正男, 山口和彦]
通讯作者:
山口和彦
DOI:
10.1073/pnas.0813341106
发表时间:
2009-03-03
期刊:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
影响因子:
11.1
作者:
[Endo, Shogo, Shutoh, Fumihiro, Ito, Masao]
通讯作者:
Ito, Masao
小脳プルキンエ細胞におけるGluR2細胞内プールの活動依存性トランスロケーションとシナプス可塑性:蛍光蛋白質2重発現法による解析
小脑浦肯野细胞中 GluR2 细胞内库的活性依赖性易位和突触可塑性:使用双荧光蛋白表达方法进行分析
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[N. Fukuda, T. Terui. I. Ohtsuki. S. Ishiwata. S. Kurihara, 尾嶋孝一, 山口和彦]
通讯作者:
山口和彦
AMPA-receptor trafficking in cerebellar Purkinje cell : A kinetic analysis.
小脑浦肯野细胞中的 AMPA 受体运输:动力学分析。
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[D. Matsuba. T. Terui. J. O-Uchi, H. Tanaka, T. Ojima, I. Ohtsuki. S. Ishiwata. S. Kurihara. N. Fukuda, 尾嶋孝一, Yamaguchi K.]
通讯作者:
Yamaguchi K.
DOI:
10.1523/jneurosci.6386-09.2010
发表时间:
2010-09-22
期刊:
JOURNAL OF NEUROSCIENCE
影响因子:
5.3
作者:
[Shiina, Nobuyuki, Yamaguchi, Kazuhiko, Tokunaga, Makio]
通讯作者:
Tokunaga, Makio
共 24 条
Elucidation of molecular mechanism of synaptic plasticity by kinetic analysis of receptor trafficking
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批准号:23500472
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.24万
-
财政年份:2011
-
负责人:YAMAGUCHI Kazuhiko
-
依托单位:
Representation of Magical Realism : Postmodernism, Postcolonialism, Americanism
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批准号:21720090
-
项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$1.66万
-
财政年份:2009
-
负责人:YAMAGUCHI Kazuhiko
-
依托单位:
Studies on Controlling the Message-Passing Decoding Algorithms and Constructing Error Correcting Codes Suitable for Such Algorithms
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批准号:16560324
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
-
财政年份:2004
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负责人:YAMAGUCHI Kazuhiko
-
依托单位:
Studies on construction of error-correcting codes and soft-input soft-output decoding
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批准号:11650374
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.15万
-
财政年份:1999
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负责人:YAMAGUCHI Kazuhiko
-
依托单位:
Elucidation of molecular mechanism of synaptic exocytosis and its modification mechanism in mammalian hippocampal autapse.
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批准号:09680819
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.86万
-
财政年份:1997
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负责人:YAMAGUCHI Kazuhiko
-
依托单位:
Investigation of the molecular mechanism of the neurite-outgrowth using a contrast enhanced camera and intracellular perfusion methods.
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批准号:02807014
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$0.96万
-
财政年份:1990
-
负责人:YAMAGUCHI Kazuhiko
-
依托单位:
海外基金