Development of vagal nerve stimulation therapy by computational management of hemodynamics in acute myocardial infarction

我研究了迷走神经刺激作为急性心肌梗死患者冠脉再通辅助治疗的临床意义。利用兔心肌缺血再灌流模型，我揭示了心肌缺血再灌流早期短期迷走神经刺激可显著减轻心脏重构，预防慢性期心力衰竭。在狗身上，我研究了直接对心脏施加电刺激是否可以增加心脏的收缩能力，从而防止不必要的副作用，如迷走神经刺激中出现的低血压。我透露，之前报道的几种方法在我的实验设置中无法不断增加收缩能力。

I investigated clinical significance of vagal nerve stimulation as an adjunct therapy to coronary reperfusion in patients with acute myocardial infarction. Using a rabbit model of myocardial ischemia reperfusion, I disclosed that early short term vagal nerve stimulation in myocardial ischemia reperfusion drastically attenuates cardiac remodeling and prevents cardiac failure in chronic phase. Using dogs, I investigated whether electrical stimulations directly applied to the heart can increase cardiac contractility thereby preventing unwanted side effects such as hypotension seen in vagal nerve stimulation. I disclosed that several methods previously reported failed to increase the contractility constantly in my experimental settings.