Development of vagal nerve stimulation therapy by computational management of hemodynamics in acute myocardial infarction

探讨迷走神经刺激作为急性心肌梗死患者冠状动脉再灌注辅助治疗的临床意义。通过家兔心肌缺血再灌注模型，我发现在心肌缺血再灌注中早期短期迷走神经刺激可显著减弱心脏重构，防止慢性期心力衰竭。我用狗来研究直接对心脏进行电刺激是否能增加心脏收缩力，从而防止不必要的副作用，如迷走神经刺激引起的低血压。我披露，在我的实验设置中，先前报道的几种方法未能持续增加收缩性。

I investigated clinical significance of vagal nerve stimulation as an adjunct therapy to coronary reperfusion in patients with acute myocardial infarction. Using a rabbit model of myocardial ischemia reperfusion, I disclosed that early short term vagal nerve stimulation in myocardial ischemia reperfusion drastically attenuates cardiac remodeling and prevents cardiac failure in chronic phase. Using dogs, I investigated whether electrical stimulations directly applied to the heart can increase cardiac contractility thereby preventing unwanted side effects such as hypotension seen in vagal nerve stimulation. I disclosed that several methods previously reported failed to increase the contractility constantly in my experimental settings.