Impacts of Ultrasound Exposure to Adipose Tissue in Metabolic Syndrome

因为单独的超声辐射不能改善脂肪细胞功能障碍，所以我们研究了常用药物作为辅助治疗的分子靶点。匹伐他汀促进脂肪细胞增殖/成熟，增加小脂肪细胞数，维持脂联素水平，改善胰岛素抵抗；吡格列酮抑制细胞周期抑制因子，增加脂肪细胞数。因此，辅助性药物的治疗性超声波将包括细胞周期抑制剂。

Because ultrasound radiation alone did not ameliorate adipocyte dysfunction, we investigated the molecular target of frequently used drugs as the adjunct therapy. Pitavastatin enhanced adipocyte proliferation/ maturation, increased small adipocyte count, preserved adiponectin level, and improved insulin resistance ; pioglitazone suppressed a cell-cycle inhibiting factor and increased adipocyte count. Thus, therapeutic ultrasound with the adjunctive drugs would include cell-cycle inhibitors.