Exercise therapy and immune function in patients with chronic respiratory failure

慢性呼吸衰竭患者的运动治疗与免疫功能

• 批准号: 20500448
• 负责人: SEKIKAWA Kiyokazu
• 金额: $ 3万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20500448/
• 关键词: 呼吸器疾患; リハビリテーション; 運動療法; 免疫; 免疫調整機能; 運動; 生体防御機能; 免疫学

The objective was to determine the effects of exercise training on changes in salivary and exhaled breath condensate (EBC) immune function in patients with chronic respiratory disease. As an indicator of an immune functions, secretary immunoglobulin A (SIgA) in saliva and EBC was measured. Airway production of SIgA was unable to be measured in EBC specimens and, therefore, EBC specimens cannot be used to monitor SIgA concentration. Hospital-based pulmonary rehabilitation program which designed exercise training and breathing retraining, did not decrease SIgA and immunity with antioxidants in saliva. The result of this study suggests that pulmonary rehabilitation could be a useful for improving immune function, also makes improving physical conditioning and exercise performance.

目的是确定运动训练对慢性呼吸道疾病患者唾液和呼出气冷凝液（EBC）免疫功能变化的影响。作为免疫功能的指标，测定唾液和EBC中的分泌型免疫球蛋白A（SIgA）。无法在EBC标本中测量气道产生的SIgA，因此，EBC标本不能用于监测SIgA浓度。以医院为基础的肺康复计划，设计了运动训练和呼吸再训练，并没有降低唾液中的抗氧化剂的SIgA和免疫力。本研究结果提示，肺功能康复治疗有助于提高机体免疫功能，改善体能，提高运动能力。

项目成果

自転車エルゴメータによる無酸素性運動負荷は酸化ストレスに影響するか?

使用自行车测力计进行无氧运动会影响氧化应激吗？

• 发表时间: 2010
• 作者: 對東俊介;堂面彩加;高橋真;関川清一;稲水惇
• 通讯作者: 稲水惇

Changes in plasma oxidative stress biomarkers after single-sprint anaerobic exercise

单次冲刺无氧运动后血浆氧化应激生物标志物的变化

• 发表时间: 2010
• 期刊: Advances in Exercise and Sports Physiology 16
• 作者: Shunsuke Taito;Fumiaki Oyama;Makoto Takahashi;Kiyokazu Sekikawa;Tsutomu Inamizu
• 通讯作者: Tsutomu Inamizu

Inamizu Tsutomu Changes in plasma oxidative stress biomarkers after single-sprint anaerobic exercise

Inamizu Tsutomu 单次冲刺无氧运动后血浆氧化应激生物标志物的变化

• 发表时间: 2010
• 期刊: Advances in Exercise and Sports Physiology 16
• 作者: Taito Shunsuke;Oyama Fumiaki;Takahashi Makoto;Sekikawa Kiyokazu
• 通讯作者: Sekikawa Kiyokazu

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Analysis of secretory immunoglobulin A concentration in saliva and exhaled breath condensate

唾液和呼出气冷凝液中分泌性免疫球蛋白 A 浓度分析

• 发表时间: 2010
• 期刊: Journal of Analytical Bio-Science 33
• 作者: Kiyokazu Sekikawa;Shunsuke Taito;Makoto Takahashi;Akemi Matsubara;Tsutomu Inamizu
• 通讯作者: Tsutomu Inamizu