Signaling examination on strategies for suppression of muscular atrophy and facilitation of restoration from muscular atrophy

本研究旨在从涉及蛋白质合成、蛋白质水解和卫星细胞的细胞内信号通路的角度阐明热应激、抗氧化剂（虾青素；Ax）或它们的组合是否可以有效抑制肌肉萎缩和促进肌肉萎缩恢复。本研究的结果表明，热应激和Ax可减轻肌肉萎缩并加速萎缩的恢复，部分原因是由于热休克蛋白促进蛋白质合成和/或抑制蛋白质降解，以及卫星细胞的激活。

This study was investigated to clarify from the point view of an intracellular signaling pathway involving protein synthesis and proteolysis, and satellite cell whether or not the heat stress, antioxidant (astaxanthin ; Ax) administration, or their combinations can be an effective strategy for suppression of muscular atrophy and facilitation of restoration from muscular atrophy. The results obtained in this study suggested that heat stress and Ax administration attenuates muscle atrophy and accelerates the recovery from atrophy, due in part, to the promotion of protein synthesis and/or the suppression of protein degradation by HSP, and the activation of satellite cells.