Etiology of Adult Disease : Stem Cell Defect Caused by Poor Nutrition in the Womb

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In this study, we have investigated the influence of malnutrition during fetal period on stem cell properties of adulthood. Two models of rat intrauterine growth retardation (IUGR), dexamethasone or rapamycin exposure were analysed for gene expression profile of offspring's bone marrow using microarray technology. As a result, protease gene expression, such as cathepsin K and granzyme B, which are indispensable for bone marrow cell migration, were altered significantly in both of IUGR models in common. This result indicates that malnutrition during fetal period may affect the function of stem cell niche in the adulthood bone marrow.