Exploration of genes involved in susceptibility to thiamin (vitamin B1) deficiency

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Wernicke-Korsakoff syndrome is a neuropsychiatric disorder resulting from thiamin deficiency (vitamin B1). It has been believed that genetic factors are important in its pathogenesis because of inter-individual and inter-regional differences in susceptibility to this disorder. In this project, we explored genetic factors by using a mouse strain which shows higher sensitivity to thiamin deficiency than the other strains. Our results from interbreeding of this strain combined with experimental thiamin deficiency suggest that multiple genes are involved in susceptibility to thiamin deficiency, and that at least one of them is located in mitochondrial DNA.