Molecular mechanisms of the neuronal production and migration in the adult zebrafish brain

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To provide new insights into the cellular and molecular mechanisms of adult neurogenesis and neuronal migration, we have studied neuronal production and migration in the adult zebrafish telencephalon. (1) Using systematic immunohistochemical and ultrastructural studies, we defined the cellular composition of the ventricular zone (VZ) in the adult zebrafish telencephalon. (2) We provided direct evidence that neuronal precursors migrate from the telencephalic VZ to the olfactory bulb in the adult zebrafish brain using a transgenic zebrafish line that expresses GFP in neuronal precursors. (3) We established a novel zebrafish model to study injury-induced neurogenesis in the adult brain.