Development of catalytic carbon-carbon-bond formation reactions and their application to analysis of pesticide residues

催化碳-碳键形成反应的进展及其在农药残留分析中的应用

• 批准号: 20550137
• 负责人: IWASA Seiji
• 金额: $ 3.24万
• 依托单位: Toyohashi University of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20550137/
• 关键词: ハプテン; 免疫化学測定法; 抗原抗体反応; 残留農薬触媒反応; ELISA; イムノアッセイ; エマメクチン; アゾキシストロビン; 触媒反応; 残留農薬; ELISA法; リンカー; センサー; 抗体

We developed a novel catalyst for carbon-carbon bond formation and successfully applied it for analysis of insecticide residues in agricultural products by a prepared mouse monoclonal antibody using enzyme-linked immunosorbeninsectitide residuest assay (ELISA). The working range was ppm-ppb level. The assay was sufficiently sensitive for analysis of the maximum residue limits in agricultural products in Japan. Our results indicate that the system we developed was useful for analysis of insecticide residues in agricultural products because rapid operation, highly accurate, flexible mobility, cheap, environmentally friendly system so on. The kits are now commercially available.

本研究开发了一种新的碳-碳键形成催化剂，并成功地将其应用于农产品中杀虫剂残留的酶联免疫- sorbenitictide residue assay （ELISA）中制备的小鼠单克隆抗体。工作范围为ppm-ppb级。该方法对日本农产品的最大残留限量分析具有足够的灵敏度。结果表明，该系统具有操作快速、准确度高、移动灵活、价格便宜、环境友好等优点，可用于农产品中农药残留的分析。这些套件现在已经可以在市场上买到。

项目成果

Creation, and breakthrough, Microporous Polymer-Supported Chiral Ru(II)-pheox Complex as an Efficient Catalyst for Enantioselective Cyclopropanation Reactions

微孔聚合物支持的手性 Ru(II)-pheox 配合物作为对映选择性环丙烷化反应的高效催化剂的创造和突破

• 发表时间: 2009
• 作者: Abdel-Moneim Abu-Elfotoh;Kesiny Phomkeona;Kazutaka Shibatomi;Seiji Iwasa
• 通讯作者: Seiji Iwasa

Novel Transition Metal Complexes for Catalytic Hydrogen Peroxide Oxidation of Phenol Derivatives

用于催化苯酚衍生物过氧化氢氧化的新型过渡金属配合物

• 发表时间: 2009
• 作者: Tsuzuki;K.;Fakhruddin;A.;Shibatomi;K.;Iwasa;S.
• 通讯作者: S.

Ru(II)- and Ir(I) Catalyzed Hydrogen Peroxide Oxidation of Hydroxamic Acids and their Subsequent Hetero Diels-Alder Cycloadditions with Chiral N-Dienyl Lactams

Ru(II)-和 Ir(I) 催化异羟肟酸的过氧化氢氧化及其随后与手性 N-二烯基内酰胺的杂狄尔斯-阿尔德环加成反应

• 发表时间: 2010
• 期刊: Letters in Organic Chemistry
• 影响因子: 0.8
• 作者: Ahmad Fakhruddin;Kesiny Phomkeona;Abdel-Moneim Abu-Elfotoh;Kazutaka Shibatomi;Seiji Iwasa
• 通讯作者: Seiji Iwasa

Design and Synthesis a Novel Microporous Polymer-Supported Chiral Ru(II) Catalyst and its Applications to Highly Stereoselective Catalytic Asymmetric Cyclopropanations

新型微孔聚合物负载手性Ru(II)催化剂的设计与合成及其在高立体选择性催化不对称环丙烷化反应中的应用

• 发表时间: 2009
• 作者: Abdel-Moneim Mohamed Abu-Elfotoh;Kesiny Phomkeona;Bounphak Lorbriayao;Ni-on Jingbaohom;Kazutaka Shibatomi;Seiji Iwasa
• 通讯作者: Seiji Iwasa

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