Enhanced xylitol fermentation based on the activation of central metabolism caused by metabolic modification

微生物利用可再生资源生产木糖醇有望实现低环境、低成本的木糖醇生产。在本研究中，为了实现利用木糖假丝酵母提高玉米芯中木糖醇的产量，我们建立了木糖代谢的简化代谢反应模型。代谢通量分析被成功地应用于木糖醇的有效生产，它不仅可以为遗传修饰提供可靠的信息，而且可以为微生物过程的操作改进提供有用的工具。

Microbial xylitol production from renewable resources is expected to have potentials to realize a cheaper production of xylitol with low environmental impact. In this study, in order to realize enhanced production of xylitol using Candida magnoliae from corn cobs, we developed a simplified metabolic reaction model concerning xylose metabolism. The metabolic flux analysis was successfully applied for effective production of xylitol and it can be a useful tool to obtain reliable information not only for genetic modification but also for operational improvements in microbial processes.