Studies on the NFkB activation via diacylglycerol kinase alpha

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Using human melanoma cells, we demonstrated that diacylglycerol kinase (DGK) alpha enhanced tumor necrosis factor-alpha (TNF-alpha)-induced activation of nuclear factor-kappaB (NF-kappaB) via protein kinase Czeta-dependent phosphorylation of a large subunit of NF-kappaB, p65/RelA. We found that the both of DGKalpha-specfic siRNA and TNF-alpha significantly attenuated the melanoma tumor growth in mice. DGKalpha is suggested to be a novel therapeutic target for melanoma.