Analysis of the metabolic syndrome using a carbohydrate chain deficient mice.

使用碳水化合物链缺陷小鼠分析代谢综合征。

• 批准号: 20570122
• 负责人: YAMASHITA Tadashi
• 金额: $ 3.16万
• 依托单位: Hokkaido University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20570122/
• 关键词: 糖鎖; 糖脂質; ノックアウトマウス; メタボリックシンドローム

A remarkable difference was observed in the liver pathology as a result of giving the calorie-rich food that caused the metabolic syndrome by using GM3 synthesis enzyme (GM3S) deficient mouse. As for a reaction of an immunity system cell, the increase of IL-6 was observed. Moreover, an increase in the amount of the cytokine under the LPS stimulation was observed in mouse embryo fibroblast (MEF) derived from GM3 knockout mouse. As for central nerve system, GM3 knockout mice showed the loss of function by behavior test. An amount of glycoprotein increased in the GM3 knockout mice.

给高热量食物引起GM3S合成酶（GM3S）缺乏小鼠的代谢综合征，结果观察到肝脏病理有显著差异。免疫系统细胞的反应是IL-6升高。此外，在LPS刺激下，GM3敲除小鼠的小鼠胚胎成纤维细胞（MEF）中细胞因子的数量增加。在中枢神经系统方面，GM3基因敲除小鼠表现为功能丧失。GM3基因敲除小鼠的糖蛋白含量增加。

项目成果

Distinct ganglioside-species specific dependencies between CD4+and CD8+T cells in the TCR-mediated activation

TCR 介导的激活中 CD4 和 CD8 T 细胞之间独特的神经节苷脂物种特异性依赖性

• 发表时间: 2009
• 作者: NAGAFUKU Masakazu;ONIMARU Yuri;YAMASHITA Tadashi;INOKUCHI Jin-ichi
• 通讯作者: INOKUCHI Jin-ichi

Glycosphingolipids Modification : Structural diversity, functional and mechanistic integration of diabetes.

鞘糖脂修饰：糖尿病的结构多样性、功能和机制整合。

• 发表时间: 2011
• 期刊: Korean Diabetes J in press
• 作者: Nagahori N;Uchida M;Kinjo M;Yamashita T.;和田啓;Yamashita T.
• 通讯作者: Yamashita T.

スフィンゴミエリン合成酵素2は、食事誘導性脂肪肝形成に関与する

鞘磷脂合酶2参与饮食诱导的脂肪肝形成

• 发表时间: 2010
• 作者: 光武進;横田はづき;座間宏太;山下匡;岡崎俊朗;渡辺研;五十嵐靖之
• 通讯作者: 五十嵐靖之

Threshold in stage-specific embryonic glycotypes uncovered by a full portrait of dynamic N-gylcan expression during cell differentiation

细胞分化过程中动态 N-聚糖表达的完整描述揭示了阶段特异性胚胎糖型的阈值

• 发表时间: 2010
• 期刊: Mol Cell Proteomics.
• 作者: Amano M;Yamaguchi M;Takegawa Y;Yamashita T;Terashima M;Furukawa J;Miura Y;Shinohara Y;Iwasaki N;Minami A;Nishimura S.
• 通讯作者: Nishimura S.

Glycosphingolipids may paly an important role for biological function -from early development to brain function-

鞘糖脂可能在生物功能中发挥重要作用 - 从早期发育到大脑功能 -

• 发表时间: 2009
• 作者: Kinouchi K.;Ichihara A.;Sano M. Sun-Wada G-H;Wada Y.;Kurauchi-Mito A.;Bokuda K.;Tadashi Yamashita
• 通讯作者: Tadashi Yamashita