Analysis of the metabolic syndrome using a carbohydrate chain deficient mice.
Analysis of the metabolic syndrome using a carbohydrate chain deficient mice.
批准号:
20570122
负责人:
YAMASHITA Tadashi
金额:
$3.16万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
A remarkable difference was observed in the liver pathology as a result of giving the calorie-rich food that caused the metabolic syndrome by using GM3 synthesis enzyme (GM3S) deficient mouse. As for a reaction of an immunity system cell, the increase of IL-6 was observed. Moreover, an increase in the amount of the cytokine under the LPS stimulation was observed in mouse embryo fibroblast (MEF) derived from GM3 knockout mouse. As for central nerve system, GM3 knockout mice showed the loss of function by behavior test. An amount of glycoprotein increased in the GM3 knockout mice.
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Distinct ganglioside-species specific dependencies between CD4+and CD8+T cells in the TCR-mediated activation
TCR 介导的激活中 CD4 和 CD8 T 细胞之间独特的神经节苷脂物种特异性依赖性
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[NAGAFUKU Masakazu, ONIMARU Yuri, YAMASHITA Tadashi, INOKUCHI Jin-ichi]
通讯作者:
INOKUCHI Jin-ichi
Glycosphingolipids Modification : Structural diversity, functional and mechanistic integration of diabetes.
鞘糖脂修饰:糖尿病的结构多样性、功能和机制整合。
DOI:
--
发表时间:
2011
期刊:
Korean Diabetes J in press
影响因子:
--
作者:
[Nagahori N, Uchida M, Kinjo M, Yamashita T., 和田啓, Yamashita T.]
通讯作者:
Yamashita T.
スフィンゴミエリン合成酵素2は、食事誘導性脂肪肝形成に関与する
鞘磷脂合酶2参与饮食诱导的脂肪肝形成
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[光武進, 横田はづき, 座間宏太, 山下匡, 岡崎俊朗, 渡辺研, 五十嵐靖之]
通讯作者:
五十嵐靖之
Threshold in stage-specific embryonic glycotypes uncovered by a full portrait of dynamic N-gylcan expression during cell differentiation
细胞分化过程中动态 N-聚糖表达的完整描述揭示了阶段特异性胚胎糖型的阈值
DOI:
--
发表时间:
2010
期刊:
Mol Cell Proteomics.
影响因子:
--
作者:
[Amano M, Yamaguchi M, Takegawa Y, Yamashita T, Terashima M, Furukawa J, Miura Y, Shinohara Y, Iwasaki N, Minami A, Nishimura S.]
通讯作者:
Nishimura S.
Glycosphingolipids may paly an important role for biological function -from early development to brain function-
鞘糖脂可能在生物功能中发挥重要作用 - 从早期发育到大脑功能 -
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Kinouchi K., Ichihara A., Sano M. Sun-Wada G-H, Wada Y., Kurauchi-Mito A., Bokuda K., Tadashi Yamashita]
通讯作者:
Tadashi Yamashita
共 32 条
Basic studies of immunoligocal function using sphingolipid-deficient mice
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批准号:24570145
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.58万
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财政年份:2012
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负责人:YAMASHITA Tadashi
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依托单位:
Development of health check-up system for postpartum women who delivered at home in the Philippines
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批准号:24792581
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$1.41万
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财政年份:2012
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负责人:YAMASHITA Tadashi
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依托单位:
Robotic Mechanism Driven Agonistically : Collision Experiment and Control of Collision Force
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批准号:06650305
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.22万
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财政年份:1994
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负责人:YAMASHITA Tadashi
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依托单位:
Dynamics and Control of Robotic Manipulation
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批准号:63550192
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.41万
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财政年份:1988
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负责人:YAMASHITA Tadashi
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依托单位:
Control Method of Robot Actuated Antagonisticaly
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批准号:61460114
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$2.37万
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财政年份:1986
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负责人:YAMASHITA Tadashi
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依托单位:
海外基金