The role of membrane phospholipids in establishment of cell polarity

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In most eukaryotic cells, cell membranes are composed of two layers that have different composition of phospholipids. We have investigated molecular mechanisms and roles of translocation of phospholipids between two layers in yeast. We identified some novel factors involved in translocation of phospholipids in the plasma membrane and a membrane protein implicated in fluidity of the plasma membrane. Moreover, an F-box protein Rcy1 is suggested to function as a mediator between vesicle formation and translocation of phospholipids catalyzed by Drs2 in endosomes.