Biosynthes is of kasugamycin, an anti-rice blast antibiotic, in heterologous microorganisms, for the creation of hybrid antibiotics

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The biosynthetic genes of kasugamycin(KSM), anti-rice blast antibiotic, and minosaminomycin(MSM), an analogue of KSM, were cloned from their producing streptomycetes. It was found that they contained kasugamine-biosynthetic genes in common, and produced KSM and MSM heterologously when introduced via a chromosomal integration vector. In addition, specific parts of MSM biosynthetic genes induced heterologous production of unknown antibiotic(s). These results seem to suggest that suitable combination of these biosynthetic genes enables to produce new antibiotic(s).