Structure and function of streptococcal system for heparin degradation/import and its involvement in infectious diseases
Structure and function of streptococcal system for heparin degradation/import and its involvement in infectious diseases
批准号:
20580078
负责人:
HASHIMOTO Wataru
金额:
$3.08万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
Pathogenic streptococci produce unsaturated glucuronyl hydrolase (UGL) together with polysaccharide lyase responsible for completely degrading glycosaminoglycans, and the streptococcal UGLs prefer sulfated substrates. This suggests that the substrate specificity is feasible for bacterial infection through degradation of mammalian extracellular matrices with sulfate groups. The motif "R-//-Sxx(S)xK" in UGL is prerequisite for degradation of sulfated substrates.
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多糖の輸送・分解に関わる細菌由来超分子の構造と機能
参与多糖转运和降解的细菌超分子的结构和功能
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Kobayashi, S.Ogawa, M., Matsumoto, M.Yoshikawa, H., 他, 橋本渉]
通讯作者:
橋本渉
Mutational studies of the peptidoglycan hydrolase FlgJ of Sphingomonas sp.strain A1
鞘氨醇单胞菌A1株肽聚糖水解酶FlgJ的突变研究
DOI:
--
发表时间:
2010
期刊:
Journal of Basic Microbiology
影响因子:
3.1
作者:
[田大輔, 村山哲也, 塩野義人, 小関卓也, Yukie Maruyama]
通讯作者:
Yukie Maruyama
Substrate specificity of streptococccal unsaturated glucuronyl hydrolases for sulfated glycosaminoglycan
链球菌不饱和葡萄糖醛酸水解酶对硫酸化糖胺聚糖的底物特异性
DOI:
--
发表时间:
2009
期刊:
Journal of Biological Chemistry 284
影响因子:
--
作者:
[鈴木健太郎, 小関卓也, 小宮大, 伏信進矢, 祥雲弘文, 若木高善, Yukie Maruyama]
通讯作者:
Yukie Maruyama
連鎖球菌由来不飽和グルクロニルヒドロラーゼのグリコサミノグリカン二糖に対する硫酸基認識
链球菌来源的不饱和葡萄糖醛酸水解酶对糖胺聚糖二糖的硫酸基识别
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[中道優介, 丸山如江, 三上文三, 橋本渉, 村田幸作]
通讯作者:
村田幸作
連鎖球菌におけるグリコサミノグリカン分解・輸送・代謝に関わる遺伝子クラスター
链球菌中参与糖胺聚糖降解、运输和代谢的基因簇
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[橋本渉, 丸山如江, 中道優介, 村田幸作]
通讯作者:
村田幸作
共 52 条
Structural life science of pathogenic bacterial systems targeting animal host extracellular matrix for colonization and infection
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批准号:15H04629
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.32万
-
财政年份:2015
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负责人:HASHIMOTO Wataru
-
依托单位:
Metabolic mechanism of host extracellular matrices, glycosaminoglycans, in streptococci
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批准号:23580112
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$3.49万
-
财政年份:2011
-
负责人:HASHIMOTO Wataru
-
依托单位:
A Study of Pressure Sensitive Spherical Projection System
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批准号:22700130
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$1.66万
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财政年份:2010
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负责人:HASHIMOTO Wataru
-
依托单位:
Spherical Projection System using Air-Filled Balloon
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批准号:20700116
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$1.25万
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财政年份:2008
-
负责人:HASHIMOTO Wataru
-
依托单位:
Molecular and structural biostudies on streptococcalinyasion/infection mechanisms to host cells through degradation of extracellular matrices glyoceaminoglycans
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批准号:18580075
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.48万
-
财政年份:2006
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负责人:HASHIMOTO Wataru
-
依托单位:
Basic research of cancer immunotherapy by using dendritic cells and clinical applications for head and neck tumors ; by using galactosylceramide
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批准号:16591980
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:2004
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负责人:HASHIMOTO Wataru
-
依托单位:
An analysis for mechanism of antitumor effects of dendritic cells treated with αGalactosylceramide
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批准号:13672079
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:2001
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负责人:HASHIMOTO Wataru
-
依托单位: