Synthetic and bioorganic studies on sarcodonins

本文对sarcodonin J的合成和sarcodonin A相关化合物的结构活性关系进行了研究。对于sarcodonin J的合成研究，从(-)- wieland - micescher酮开始，采用根岸偶联的方法基本完成了合成路线。在对sarcodonin A相关化合物的构效关系研究中，C-14位的羟基对其抗炎活性具有极其重要的作用。

Synthetic studies on sarcodonin J and structural activity relationship study on sarcodonin A related compounds were performed. As to the synthetic study on sarcodonin J, synthetic route was almost accomplished using Negishi coupling starting from (-)-Wieland-Miescher ketone. As to the structural activity relationship study on sarcodonin A related compounds, the hydroxyl group at C-14 position proved to be extremely important for the anti-inflammatory activity.