Regulation of osteoclastogenesis by protein phosphatase 2C

蛋白磷酸酶 2C 对破骨细胞生成的调节

• 批准号: 20580105
• 负责人: OHNISHI Motoko
• 金额: $ 3万
• 依托单位: Chubu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20580105/
• 关键词: プロテインホスファターゼ; 破骨細胞; 破骨細胞分化因子; シグナル伝達; RANKL; プロティンホスファターゼ2C; 発生・分化; 酵素; 生理活性; 細胞・組織

Bone continuously undergoes remodeling, in which bone resorption by osteoclasts is followed by bone formation by osteoblasts, and maintains its structure and function. An imbalance in the regulation of bone remodeling results in many metabolic bone diseases, such as osteoporosis. Here we show that a low molecular weight compound which specifically activates protein phosphatase 2C(PP2C)suppressed osteoclastogenesis, and how it acts on the RANKL induced osteoclast differentiation.

骨不断经历重塑，其中破骨细胞的骨吸收随后是成骨细胞的骨形成，并保持其结构和功能。骨重建调节的失衡导致许多代谢性骨病，如骨质疏松症。在这里，我们表明，低分子量的化合物，特异性激活蛋白磷酸酶2C（PP2C）抑制破骨细胞生成，以及它如何作用于RANKL诱导的破骨细胞分化。

项目成果

Suppression of osteoclast differentiation by pisiferdiol, an activatorof protein phosphatase 2C.

pisiferdiol（蛋白磷酸酶 2C 的激活剂）抑制破骨细胞分化。

• 发表时间: 2008
• 作者: 高上馬;ら;Mami Yoshida
• 通讯作者: Mami Yoshida

An Inhibitory Effect of Chrysoeriol on Platelet-Derived Growth Factor (PDGF)-Induced Proliferation and PDGF Receptor Signaling in Human Aortic Smooth Muscle Cells

• DOI: 10.1254/jphs.08282fp
• 发表时间: 2009-05-01
• 期刊: JOURNAL OF PHARMACOLOGICAL SCIENCES
• 影响因子: 3.5
• 作者: Cha, Byung-Yoon;Shi, Wen Lei;Woo, Je-Tae
• 通讯作者: Woo, Je-Tae

Pisiferdiol and pisiferic acid isolated from Chamaecyparis pisifera activate protein phosphatase 2C in vitro and induce caspase-3/7-dependent apoptosis via dephosphorylation of Bad in HL60 cells.

• DOI: 10.1016/j.phymed.2009.12.015
• 发表时间: 2010-08
• 期刊: Phytomedicine : international journal of phytotherapy and phytopharmacology
• 作者: N. Aburai;M. Yoshida;M. Ohnishi;K. Kimura

卵巣摘出マウスの骨密度低下に対するホノキオールの抑制効果

和厚朴酚对去卵巢小鼠骨密度下降的抑制作用

• 发表时间: 2010
• 作者: 浅井みどり;ら
• 通讯作者: ら

Sanguinarine as a Potent and Specific Inhibitor of Protein Phosphatase 2C in Vitro and Induces Apoptosis via Phosphorylation of p38 in HL60 Cells

• DOI: 10.1271/bbb.90735
• 发表时间: 2010-03-01
• 期刊: BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
• 影响因子: 1.6
• 作者: Aburai, Nobuhiro;Yoshida, Mami;Kimura, Ken-ichi
• 通讯作者: Kimura, Ken-ichi